Minimal Change Disease
Leading cause of nephrotic syndrome with microscopic glomerular injury.
What it is
Glomerular damage so subtle it requires electron microscopy, yet drives nephrotic syndrome in children.
Prevalence
10–50 cases per 100,000 children; 2–7 new cases per 100,000 kids each year.
Symptoms to watch
Sudden swelling of face, abdomen, hands, feet; foamy urine; weight gain; high blood pressure; high cholesterol; clot risk.
Treatment options
Corticosteroids first-line, ACE inhibitors, diuretics, sodium restriction, regular exercise, scheduled follow-ups.
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